2QT6

Crystal Structure Determination of a Blue Laccase from Lentinus Tigrinus

2QT6 の概要

• エントリーDOI: 10.2210/pdb2qt6/pdb
• 分子名称: Laccase, CALCIUM ION, CHLORIDE ION, ... (13 entities in total)
• 機能のキーワード: beta barrel, oxidoreductase
• 由来する生物種: Lentinus tigrinus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112748.57

構造登録者

Ferraroni, M.,Briganti, F.,Scozzafava, A. (登録日: 2007-08-01, 公開日: 2007-11-20, 最終更新日: 2024-12-25)

主引用文献

Ferraroni, M.,Myasoedova, N.M.,Schmatchenko, V.,Leontievsky, A.A.,Golovleva, L.A.,Scozzafava, A.,Briganti, F.
Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.
Bmc Struct.Biol., 7:60-60, 2007

PubMed Abstract: Laccases belong to multicopper oxidases, a widespread class of enzymes implicated in many oxidative functions in pathogenesis, immunogenesis and morphogenesis of organisms and in the metabolic turnover of complex organic substances. They catalyze the coupling between the four one-electron oxidations of a broad range of substrates with the four-electron reduction of dioxygen to water. These catalytic processes are made possible by the contemporaneous presence of at least four copper ion sites, classified according to their spectroscopic properties: one type 1 (T1) site where the electrons from the reducing substrates are accepted, one type 2 (T2), and a coupled binuclear type 3 pair (T3) which are assembled in a T2/T3 trinuclear cluster where the electrons are transferred to perform the O2 reduction to H2O.

PubMed: 17897461
DOI: 10.1186/1472-6807-7-60

実験手法

X-RAY DIFFRACTION (1.5 Å)