2QP6
The crystal structure of the complex of hcaII with a bioreductive antitumor derivative
Summary for 2QP6
Entry DOI | 10.2210/pdb2qp6/pdb |
Related | 1CA2 2QO8 2QOA |
Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | carbonic anhydrase ii, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30017.65 |
Authors | D'Ambrosio, K.,De Simone, G. (deposition date: 2007-07-23, release date: 2008-06-03, Last modification date: 2023-08-30) |
Primary citation | D'Ambrosio, K.,Vitale, R.M.,Dogne, J.M.,Masereel, B.,Innocenti, A.,Scozzafava, A.,De Simone, G.,Supuran, C.T. Carbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides with Selectivity for Targeting the Tumor Associated Isoforms IX and XII. J.Med.Chem., 51:3230-3237, 2008 Cited by PubMed: 18481843DOI: 10.1021/jm800121c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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