2QMS

Crystal structure of a signaling molecule

2QMS の概要

• エントリーDOI: 10.2210/pdb2qms/pdb
• 分子名称: Growth factor receptor-bound protein 7, SULFATE ION (3 entities in total)
• 機能のキーワード: sh2 domain, alpha/beta fold, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 55435.28

構造登録者

Porter, C.J.,Wilce, M.C.,Wilce, J.A. (登録日: 2007-07-16, 公開日: 2008-07-22, 最終更新日: 2024-02-21)

主引用文献

Porter, C.J.,Matthews, J.M.,Mackay, J.P.,Pursglove, S.E.,Schmidberger, J.W.,Leedman, P.J.,Pero, S.C.,Krag, D.N.,Wilce, M.C.,Wilce, J.A.
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Bmc Struct.Biol., 7:58-58, 2007

PubMed Abstract: Human growth factor receptor bound protein 7 (Grb7) is an adapter protein that mediates the coupling of tyrosine kinases with their downstream signaling pathways. Grb7 is frequently overexpressed in invasive and metastatic human cancers and is implicated in cancer progression via its interaction with the ErbB2 receptor and focal adhesion kinase (FAK) that play critical roles in cell proliferation and migration. It is thus a prime target for the development of novel anti-cancer therapies. Recently, an inhibitory peptide (G7-18NATE) has been developed which binds specifically to the Grb7 SH2 domain and is able to attenuate cancer cell proliferation and migration in various cancer cell lines.

PubMed: 17894853
DOI: 10.1186/1472-6807-7-58

実験手法

X-RAY DIFFRACTION (2.1 Å)