2QLD

human Hsp40 Hdj1

Summary for 2QLD

• Entry DOI: 10.2210/pdb2qld/pdb
• Descriptor: DnaJ homolog subfamily B member 1 (1 entity in total)
• Functional Keywords: primarily beta sheets, chaperone
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P25685
• Total number of polymer chains: 1
• Total formula weight: 20737.21

Authors

Hu, J.,Wu, Y.,Li, J.,Fu, Z.,Sha, B. (deposition date: 2007-07-12, release date: 2008-07-15, Last modification date: 2024-04-03)

Primary citation

Hu, J.,Wu, Y.,Li, J.,Qian, X.,Fu, Z.,Sha, B.
The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1.
Bmc Struct.Biol., 8:3-3, 2008

PubMed Abstract: The mechanism by which Hsp40 and other molecular chaperones recognize and interact with non-native polypeptides is a fundamental question. How Hsp40 co-operates with Hsp70 to facilitate protein folding is not well understood. To investigate the mechanisms, we determined the crystal structure of the putative peptide-binding fragment of Hdj1, a human member of the type II Hsp40 family.

PubMed: 18211704
DOI: 10.1186/1472-6807-8-3

Experimental method

X-RAY DIFFRACTION (2.7 Å)