2QJU

Crystal Structure of an NSS Homolog with Bound Antidepressant

Summary for 2QJU

• Entry DOI: 10.2210/pdb2qju/pdb
• Related: 2A65
• Descriptor: Transporter, octyl beta-D-glucopyranoside, SODIUM ION, ... (7 entities in total)
• Functional Keywords: neurotransmitter, transmembrane transport, integral membrane protein, antidepressant, nss, transport protein, structural genomics, psi-2, protein structure initiative, new york consortium on membrane protein structure, nycomps
• Biological source: Aquifex aeolicus
• Total number of polymer chains: 1
• Total formula weight: 58770.69

Authors

Zhou, Z.,Karpowich, N.K.,Wang, D.N.,New York Consortium on Membrane Protein Structure (NYCOMPS) (deposition date: 2007-07-09, release date: 2007-08-21, Last modification date: 2023-08-30)

• Primary citation: Zhou, Z.,Zhen, J.,Karpowich, N.K.,Goetz, R.M.,Law, C.J.,Reith, M.E.,Wang, D.N.; LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.; Science, 317:1390-1393, 2007; PubMed: 17690258; DOI: 10.1126/science.1147614

Experimental method

X-RAY DIFFRACTION (2.9 Å)