2QIQ
Structure-based Design and Synthesis and Biological Evaluation of Peptidomimetic SARS-3CLpro Inhibitors
2QIQ の概要
エントリーDOI | 10.2210/pdb2qiq/pdb |
関連するPDBエントリー | 2ALV |
分子名称 | Replicase polyprotein 1ab, ETHYL (4R)-4-{[(2R,5S)-5-{[N-(TERT-BUTOXYCARBONYL)-L-SERYL]AMINO}-6-METHYL-2-(3-METHYLBUT-2-EN-1-YL)-4-OXOHEPTANOYL]AMINO}-5-[(3R)-2-OXOPYRROLIDIN-3-YL]PENTANOATE (3 entities in total) |
機能のキーワード | hydrolase, viral protein |
由来する生物種 | SARS coronavirus |
細胞内の位置 | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 33966.85 |
構造登録者 | |
主引用文献 | Ghosh, A.K.,Xi, K.,Grum-Tokars, V.,Xu, X.,Ratia, K.,Fu, W.,Houser, K.V.,Baker, S.C.,Johnson, M.E.,Mesecar, A.D. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorg.Med.Chem.Lett., 17:5876-5880, 2007 Cited by PubMed: 17855091DOI: 10.1016/j.bmcl.2007.08.031 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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