2QIL

TOXIC SHOCK SYNDROME TOXIN-1 AT 2.07 A RESOLUTION

Summary for 2QIL

• Entry DOI: 10.2210/pdb2qil/pdb
• Descriptor: TOXIC SHOCK SYNDROME TOXIN-1 (2 entities in total)
• Functional Keywords: staphylococcal enterotoxin, superantigen, toxic shock syndrome toxin
• Biological source: Staphylococcus aureus
• Cellular location: Secreted: P06886
• Total number of polymer chains: 3
• Total formula weight: 66311.31

Authors

Acharya, K.R.,Papageorgiou, A.C. (deposition date: 1997-03-27, release date: 1997-08-12, Last modification date: 2024-02-21)

Primary citation

Papageorgiou, A.C.,Brehm, R.D.,Leonidas, D.D.,Tranter, H.S.,Acharya, K.R.
The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.
J.Mol.Biol., 260:553-569, 1996

PubMed Abstract: The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecules and T-cell receptors leading to the activation of a substantial number of T cells. The crystal structure of this protein has been refined to 2.07 A with an Rcryst value of 20.4% for 51,240 reflections. The final model contains three molecules in the asymmetric unit with good stereochemistry and a root-mean-square deviation of 0.009 A and 1.63 from ideality for bond lengths and bond angles, respectively. The overall fold is considerably similar to that of other known microbial superantigens (staphylococcal enterotoxins). However, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural features that affect its specificity for V beta elements of the T-cell receptor and also its recognition by major histocompatibility class II molecules.

PubMed: 8759320
DOI: 10.1006/jmbi.1996.0421

Experimental method

X-RAY DIFFRACTION (2.07 Å)