2QIL

TOXIC SHOCK SYNDROME TOXIN-1 AT 2.07 A RESOLUTION

2QIL の概要

• エントリーDOI: 10.2210/pdb2qil/pdb
• 分子名称: TOXIC SHOCK SYNDROME TOXIN-1 (2 entities in total)
• 機能のキーワード: staphylococcal enterotoxin, superantigen, toxic shock syndrome toxin
• 由来する生物種: Staphylococcus aureus
• 細胞内の位置: Secreted: P06886
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 66311.31

構造登録者

Acharya, K.R.,Papageorgiou, A.C. (登録日: 1997-03-27, 公開日: 1997-08-12, 最終更新日: 2024-02-21)

主引用文献

Papageorgiou, A.C.,Brehm, R.D.,Leonidas, D.D.,Tranter, H.S.,Acharya, K.R.
The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution.
J.Mol.Biol., 260:553-569, 1996

PubMed Abstract: The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecules and T-cell receptors leading to the activation of a substantial number of T cells. The crystal structure of this protein has been refined to 2.07 A with an Rcryst value of 20.4% for 51,240 reflections. The final model contains three molecules in the asymmetric unit with good stereochemistry and a root-mean-square deviation of 0.009 A and 1.63 from ideality for bond lengths and bond angles, respectively. The overall fold is considerably similar to that of other known microbial superantigens (staphylococcal enterotoxins). However, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural features that affect its specificity for V beta elements of the T-cell receptor and also its recognition by major histocompatibility class II molecules.

PubMed: 8759320
DOI: 10.1006/jmbi.1996.0421

実験手法

X-RAY DIFFRACTION (2.07 Å)