2QHL
Crystal Structure of Novel Immune-Type Receptor 10 Extracellular Fragment from Ictalurus punctatus
Summary for 2QHL
| Entry DOI | 10.2210/pdb2qhl/pdb |
| Descriptor | Novel immune-type receptor 10 (2 entities in total) |
| Functional Keywords | immunoglobulin variable domain-like beta-sandwich, immune-type receptor, immune system |
| Biological source | Ictalurus punctatus (Channel catfish) |
| Total number of polymer chains | 5 |
| Total formula weight | 64532.68 |
| Authors | Ostrov, D.A.,Hernandez Prada, J.A.,Haire, R.N.,Cannon, J.P.,Magis, A.T.,Bailey, K.M.,Litman, G.W. (deposition date: 2007-07-02, release date: 2008-06-24, Last modification date: 2024-10-30) |
| Primary citation | Cannon, J.P.,Haire, R.N.,Magis, A.T.,Eason, D.D.,Winfrey, K.N.,Hernandez Prada, J.A.,Bailey, K.M.,Jakoncic, J.,Litman, G.W.,Ostrov, D.A. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity, 29:228-237, 2008 Cited by PubMed Abstract: Novel immune-type receptors (NITRs) comprise an exceptionally large, diversified family of activating and inhibitory receptors that has been identified in bony fish. Here, we characterized the structure of an activating NITR that is expressed by a cytotoxic natural killer (NK)-like cell line and that specifically binds an allogeneic B cell target. A single amino acid residue within the NITR immunoglobulin variable (V)-type domain accounts for specificity of the interaction. Structures solved by X-ray crystallography revealed that the V-type domains of NITRs form homodimers resembling rearranging antigen-binding receptor heterodimers. CDR1 elements of both subunits of NITR dimers form ligand-binding surfaces that determine specificity for the nonself target. In the evolution of immune function, it appears that a specific NK type of innate recognition may be mediated by a complex germline multigene family of V structures resembling those that are somatically diversified in adaptive immunological responses. PubMed: 18674935DOI: 10.1016/j.immuni.2008.05.018 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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