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2QGT

Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to an Ether Estradiol Compound

Summary for 2QGT
Entry DOI10.2210/pdb2qgt/pdb
Related2QA6 2QA8 2QAB 2QGW 2QH6
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus : Q8BN74
Total number of polymer chains4
Total formula weight62565.82
Authors
Primary citationNettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L.
NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
Nat.Chem.Biol., 4:241-247, 2008
Cited by
PubMed: 18344977
DOI: 10.1038/nchembio.76
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

218853

數據於2024-04-24公開中

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