2QFP

Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride

2QFP の概要

• エントリーDOI: 10.2210/pdb2qfp/pdb
• 関連するPDBエントリー: 2QFR 3KBP 4KBP
• 分子名称: Purple acid phosphatase, FE (III) ION, ZINC ION, ... (8 entities in total)
• 機能のキーワード: binuclear, fe-zn, hydrolase
• 由来する生物種: Phaseolus vulgaris (Kidney bean)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 202370.20

構造登録者

Guddat, L.W.,Schenk, G.S.,Gahan, L.R.,Elliot, T.W.,Leung, E. (登録日: 2007-06-27, 公開日: 2008-10-14, 最終更新日: 2024-10-30)

主引用文献

Schenk, G.,Elliott, T.W.,Leung, E.,Carrington, L.E.,Mitic, N.,Gahan, L.R.,Guddat, L.W.
Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle.
Bmc Struct.Biol., 8:6-6, 2008

PubMed Abstract: Purple acid phosphatases belong to the family of binuclear metallohydrolases and are involved in a multitude of biological functions, ranging from bacterial killing and bone metabolism in animals to phosphate uptake in plants. Due to its role in bone resorption purple acid phosphatase has evolved into a promising target for the development of anti-osteoporotic chemotherapeutics. The design of specific and potent inhibitors for this enzyme is aided by detailed knowledge of its reaction mechanism. However, despite considerable effort in the last 10 years various aspects of the basic molecular mechanism of action are still not fully understood.

PubMed: 18234116
DOI: 10.1186/1472-6807-8-6

実験手法

X-RAY DIFFRACTION (2.2 Å)