2QFO

HSP90 complexed with A143571 and A516383

Summary for 2QFO

DescriptorHeat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains2
Total molecular weight46634.78
Authors
Park, C.H. (deposition date: 2007-06-27, release date: 2008-07-01, Last modification date: 2014-04-16)
Primary citation
Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
CHEM.BIOL.DRUG DES., 70:1-12, 2007
PubMed: 17630989 (PDB entries with the same primary citation)
DOI: 10.1111/j.1747-0285.2007.00535.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.68 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers70.2%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2qfo
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Molmil generated image of 2qfo
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Molmil generated image of 2qfo
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More Biological unit images

Molmil generated image of 2qfo
no rotation
Molmil generated image of 2qfo
rotated about x axis by 90°
Molmil generated image of 2qfo
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2qfo.pdb1.gz [38.1 KB])
Coordinate files for Biological unit (2qfo.pdb2.gz [37.4 KB])