2QFO

HSP90 complexed with A143571 and A516383

2QFO の概要

• エントリーDOI: 10.2210/pdb2qfo/pdb
• 分子名称: Heat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46634.78

構造登録者

Park, C.H. (登録日: 2007-06-27, 公開日: 2008-07-01, 最終更新日: 2023-08-30)

• 主引用文献: Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.; Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.; CHEM.BIOL.DRUG DES., 70:1-12, 2007; PubMed: 17630989; DOI: 10.1111/j.1747-0285.2007.00535.x

実験手法

X-RAY DIFFRACTION (1.68 Å)