2QFO

HSP90 complexed with A143571 and A516383

2QFO の概要

分子名称Heat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one, ... (4 entities in total)
機能のキーワードprotein-inhibitor complex, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm P07900
ポリマー鎖数2
分子量合計46634.78
構造登録者
Park, C.H. (登録日: 2007-06-27, 公開日: 2008-07-01, 最終更新日: 2014-04-16)
主引用文献
Huth, J.R.,Park, C.,Petros, A.M.,Kunzer, A.R.,Wendt, M.D.,Wang, X.,Lynch, C.L.,Mack, J.C.,Swift, K.M.,Judge, R.A.,Chen, J.,Richardson, P.L.,Jin, S.,Tahir, S.K.,Matayoshi, E.D.,Dorwin, S.A.,Ladror, U.S.,Severin, J.M.,Walter, K.A.,Bartley, D.M.,Fesik, S.W.,Elmore, S.W.,Hajduk, P.J.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
CHEM.BIOL.DRUG DES., 70:1-12, 2007
PubMed: 17630989 (主引用文献が同じPDBエントリー)
DOI: 10.1111/j.1747-0285.2007.00535.x
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.68 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers70.2%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード