2QDF

Structure of N-terminal domain of E. Coli YaeT

2QDF の概要

• エントリーDOI: 10.2210/pdb2qdf/pdb
• 関連するPDBエントリー: 2QCZ
• 分子名称: Outer membrane protein assembly factor yaeT, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: potra domain, membrane protein, protein transport
• 由来する生物種: Escherichia coli K12
• 細胞内の位置: Cell outer membrane : P0A940
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37479.47

構造登録者

Kim, S.,Malinverni, J.C.,Sliz, P.,Silhavy, T.J.,Harrison, S.C.,Kahne, D. (登録日: 2007-06-20, 公開日: 2007-09-04, 最終更新日: 2023-08-30)

主引用文献

Kim, S.,Malinverni, J.C.,Sliz, P.,Silhavy, T.J.,Harrison, S.C.,Kahne, D.
Structure and function of an essential component of the outer membrane protein assembly machine.
Science, 317:961-964, 2007

PubMed Abstract: Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.

PubMed: 17702946
DOI: 10.1126/science.1143993

実験手法

X-RAY DIFFRACTION (2.2 Å)