2QD9

P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds

2QD9 の概要

• エントリーDOI: 10.2210/pdb2qd9/pdb
• 分子名称: Mitogen-activated protein kinase 14, 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione (3 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, kinase, transferase, p38 map kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42655.52

構造登録者

Sack, J.S. (登録日: 2007-06-20, 公開日: 2007-08-21, 最終更新日: 2024-02-21)

• 主引用文献: Murali Dhar, T.G.,Wrobleski, S.T.,Lin, S.,Furch, J.A.,Nirschl, D.S.,Fan, Y.,Todderud, G.,Pitt, S.,Doweyko, A.M.,Sack, J.S.,Mathur, A.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K.; Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.; Bioorg.Med.Chem.Lett., 17:5019-5024, 2007; PubMed: 17664068; DOI: 10.1016/j.bmcl.2007.07.029

実験手法