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2QBT

Structural Studies Reveal The Inactivation of E. coli L-aspartate aminotransferase by (S)-4,5-amino-dihydro-2-thiophenecarboxylic acid (SADTA) via Two Mechanisms (at pH 8.0)

Summary for 2QBT
Entry DOI10.2210/pdb2qbt/pdb
Related2Q7W 2QA3 2QB2 2QB3
DescriptorAspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ... (6 entities in total)
Functional Keywordsmechanism-based inactivator, ph dependence, aspartate aminotransferase, sadta, plp, transferase
Biological sourceEscherichia coli
Cellular locationCytoplasm: P00509
Total number of polymer chains1
Total formula weight45391.76
Authors
Liu, D.,Pozharski, E.,Lepore, B.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D. (deposition date: 2007-06-18, release date: 2007-09-04, Last modification date: 2023-08-30)
Primary citationLiu, D.,Pozharski, E.,Lepore, B.W.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D.
Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46:10517-10527, 2007
Cited by
PubMed: 17713924
DOI: 10.1021/bi700663n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

数据于2024-03-27公开中

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