2QB2

Structural Studies Reveal the Inactivation of E. coli L-aspartate aminotransferase by (s)-4,5-dihydro-2thiophenecarboylic acid (SADTA) via two mechanisms (at pH 7.0).

2QB2 の概要

• エントリーDOI: 10.2210/pdb2qb2/pdb
• 関連するPDBエントリー: 2Q7W 2QA3 2QB3
• 分子名称: Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ... (6 entities in total)
• 機能のキーワード: mechanism-based inactivator, ph dependence, aspartate aminotransferase, sadta, plp, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P00509
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45664.07

構造登録者

Liu, D.,Pozharski, E.,Lepore, B.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D. (登録日: 2007-06-15, 公開日: 2007-12-04, 最終更新日: 2023-08-30)

• 主引用文献: Liu, D.,Pozharski, E.,Lepore, B.W.,Fu, M.,Silverman, R.B.,Petsko, G.A.,Ringe, D.; Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".; Biochemistry, 46:10517-10527, 2007; PubMed: 17713924; DOI: 10.1021/bi700663n

実験手法

X-RAY DIFFRACTION (1.7 Å)