2Q93

E. coli methionine aminopeptidase Mn-form with inhibitor B21

2Q93 の概要

• エントリーDOI: 10.2210/pdb2q93/pdb
• 関連するPDBエントリー: 1xnz 2evc 2evm 2gtx 2Q92 2Q94 2Q95 2Q96
• 分子名称: Methionine aminopeptidase, MANGANESE (II) ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: aminopeptidase, hydrolase, dinuclear, mn(ii)-form, enzyme-inhibitor complex, metalloenzyme
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29590.71

構造登録者

Ye, Q.-Z. (登録日: 2007-06-12, 公開日: 2008-01-01, 最終更新日: 2023-08-30)

主引用文献

Ma, Z.Q.,Xie, S.X.,Huang, Q.Q.,Nan, F.J.,Hurley, T.D.,Ye, Q.Z.
Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
Bmc Struct.Biol., 7:84-84, 2007

PubMed Abstract: Methionine aminopeptidase is a potential target of future antibacterial and anticancer drugs. Structural analysis of complexes of the enzyme with its inhibitors provides valuable information for structure-based drug design efforts.

PubMed: 18093325
DOI: 10.1186/1472-6807-7-84

実験手法

X-RAY DIFFRACTION (1.6 Å)