2Q74

Mycobacterium tuberculosis SuhB

2Q74 の概要

• エントリーDOI: 10.2210/pdb2q74/pdb
• 分子名称: Inositol-1-monophosphatase (2 entities in total)
• 機能のキーワード: alpha-beta-alpha-beta-alpha sandwich, hydrolase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 93603.65

構造登録者

Brown, A.K.,Meng, G.,Ghadbane, H.,Besra, G.S.,Futterer, K. (登録日: 2007-06-06, 公開日: 2007-10-23, 最終更新日: 2023-08-30)

主引用文献

Brown, A.K.,Meng, G.,Ghadbane, H.,Scott, D.J.,Dover, L.G.,Nigou, J.,Besra, G.S.,Futterer, K.
Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
Bmc Struct.Biol., 7:55-55, 2007

PubMed Abstract: The cell wall of Mycobacterium tuberculosis contains a wide range of phosphatidyl inositol-based glycolipids that play critical structural roles and, in part, govern pathogen-host interactions. Synthesis of phosphatidyl inositol is dependent on free myo-inositol, generated through dephosphorylation of myo-inositol-1-phosphate by inositol monophosphatase (IMPase). Human IMPase, the putative target of lithium therapy, has been studied extensively, but the function of four IMPase-like genes in M. tuberculosis is unclear.

PubMed: 17725819
DOI: 10.1186/1472-6807-7-55

実験手法

X-RAY DIFFRACTION (2.6 Å)