2Q6G

Crystal structure of SARS-CoV main protease H41A mutant in complex with an N-terminal substrate

Summary for 2Q6G

Related2Q6D 2Q6F
Descriptorsevere acute respiratory syndrome coronavirus (SARS-CoV), Polypeptide chain (3 entities in total)
Functional Keywordscoronavirus; sars-cov; main protease; 3c-like proteinase;substrate, hydrolase
Biological sourceSARS coronavirus
More
Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity) P59641
Total number of polymer chains4
Total molecular weight70009.87
Authors
Xue, X.Y.,Yang, H.T.,Xue, F.,Bartlam, M.,Rao, Z.H. (deposition date: 2007-06-05, release date: 2008-02-12, Last modification date: 2011-07-13)
Primary citation
Xue, X.,Yu, H.,Yang, H.,Xue, F.,Wu, Z.,Shen, W.,Li, J.,Zhou, Z.,Ding, Y.,Zhao, Q.,Zhang, X.C.,Liao, M.,Bartlam, M.,Rao, Z.
Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
J.Virol., 82:2515-2527, 2008
PubMed: 18094151 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.02114-07
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266200.5%5.6%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution