2Q6G

Crystal structure of SARS-CoV main protease H41A mutant in complex with an N-terminal substrate

2Q6G の概要

• エントリーDOI: 10.2210/pdb2q6g/pdb
• 関連するPDBエントリー: 2Q6D 2Q6F
• 分子名称: severe acute respiratory syndrome coronavirus (SARS-CoV), Polypeptide chain (3 entities in total)
• 機能のキーワード: coronavirus; sars-cov; main protease; 3c-like proteinase;substrate, hydrolase
• 由来する生物種: SARS coronavirus; 詳細
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70009.87

構造登録者

Xue, X.Y.,Yang, H.T.,Xue, F.,Bartlam, M.,Rao, Z.H. (登録日: 2007-06-05, 公開日: 2008-02-12, 最終更新日: 2023-08-30)

• 主引用文献: Xue, X.,Yu, H.,Yang, H.,Xue, F.,Wu, Z.,Shen, W.,Li, J.,Zhou, Z.,Ding, Y.,Zhao, Q.,Zhang, X.C.,Liao, M.,Bartlam, M.,Rao, Z.; Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.; J.Virol., 82:2515-2527, 2008; PubMed: 18094151; DOI: 10.1128/JVI.02114-07

実験手法

X-RAY DIFFRACTION (2.5 Å)