2Q6F
Crystal structure of infectious bronchitis virus (IBV) main protease in complex with a Michael acceptor inhibitor N3
Summary for 2Q6F
Entry DOI | 10.2210/pdb2q6f/pdb |
Related | 2Q6D 2Q6G |
Related PRD ID | PRD_002214 |
Descriptor | Infectious bronchitis virus (IBV) main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total) |
Functional Keywords | coronavirus; ibv; main protease; 3c-like proteinase; michael acceptor inhibitor, hydrolase |
Biological source | Infectious bronchitis virus More |
Total number of polymer chains | 4 |
Total formula weight | 68633.48 |
Authors | Xue, X.Y.,Yang, H.T.,Xue, F.,Bartlam, M.,Rao, Z.H. (deposition date: 2007-06-05, release date: 2008-02-12, Last modification date: 2023-11-15) |
Primary citation | Xue, X.,Yu, H.,Yang, H.,Xue, F.,Wu, Z.,Shen, W.,Li, J.,Zhou, Z.,Ding, Y.,Zhao, Q.,Zhang, X.C.,Liao, M.,Bartlam, M.,Rao, Z. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J.Virol., 82:2515-2527, 2008 Cited by PubMed: 18094151DOI: 10.1128/JVI.02114-07 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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