2Q64
HIV-1 PR mutant in complex with nelfinavir
Summary for 2Q64
Entry DOI | 10.2210/pdb2q64/pdb |
Related | 2PYM 2PYN 2Q63 2QAK |
Descriptor | PROTEASE RETROPEPSIN, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total) |
Functional Keywords | resistance; nelfinavir, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22001.09 |
Authors | Rezacova, P.,Kozisek, M.,Saskova, K.,Brynda, J.,Konvalinka, J. (deposition date: 2007-06-04, release date: 2008-02-26, Last modification date: 2023-08-30) |
Primary citation | Kozisek, M.,Bray, J.,Rezacova, P.,Saskova, K.,Brynda, J.,Pokorna, J.,Mammano, F.,Rulisek, L.,Konvalinka, J. Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants J.Mol.Biol., 374:1005-1016, 2007 Cited by PubMed: 17977555DOI: 10.1016/j.jmb.2007.09.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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