2Q1O
Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
Summary for 2Q1O
Entry DOI | 10.2210/pdb2q1o/pdb |
Descriptor | RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') (2 entities in total) |
Functional Keywords | 2, 4-difluorotoluyl nucleoside, chemical modification, rna, rnai, hydrogen bond |
Total number of polymer chains | 4 |
Total formula weight | 15377.41 |
Authors | Li, F.,Pallan, P.S. (deposition date: 2007-05-25, release date: 2007-10-30, Last modification date: 2024-04-03) |
Primary citation | Li, F.,Pallan, P.S.,Maier, M.A.,Rajeev, K.G.,Mathieu, S.L.,Kreutz, C.,Fan, Y.,Sanghvi, J.,Micura, R.,Rozners, E.,Manoharan, M.,Egli, M. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme. Nucleic Acids Res., 35:6424-6438, 2007 Cited by PubMed: 17881374DOI: 10.1093/nar/gkm664 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
Download full validation report