2Q1O

Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)

2Q1O の概要

• エントリーDOI: 10.2210/pdb2q1o/pdb
• 分子名称: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') (2 entities in total)
• 機能のキーワード: 2, 4-difluorotoluyl nucleoside, chemical modification, rna, rnai, hydrogen bond
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 15377.41

構造登録者

Li, F.,Pallan, P.S. (登録日: 2007-05-25, 公開日: 2007-10-30, 最終更新日: 2024-04-03)

• 主引用文献: Li, F.,Pallan, P.S.,Maier, M.A.,Rajeev, K.G.,Mathieu, S.L.,Kreutz, C.,Fan, Y.,Sanghvi, J.,Micura, R.,Rozners, E.,Manoharan, M.,Egli, M.; Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.; Nucleic Acids Res., 35:6424-6438, 2007; PubMed: 17881374; DOI: 10.1093/nar/gkm664

実験手法

X-RAY DIFFRACTION (1.1 Å)