2Q1L

Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors

2Q1L の概要

• エントリーDOI: 10.2210/pdb2q1l/pdb
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID (3 entities in total)
• 機能のキーワード: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192224.72

構造登録者

Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (登録日: 2007-05-24, 公開日: 2007-07-17, 最終更新日: 2024-02-21)

• 主引用文献: Pfefferkorn, J.A.,Song, Y.,Sun, K.L.,Miller, S.R.,Trivedi, B.K.,Choi, C.,Sorenson, R.J.,Bratton, L.D.,Unangst, P.C.,Larsen, S.D.,Poel, T.J.,Cheng, X.M.,Lee, C.,Erasga, N.,Auerbach, B.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.,Robertson, A.,Olsen, K.,Mertz, T.,Sekerke, C.,Pavlovsky, A.,Harris, M.S.,Bainbridge, G.,Caspers, N.,Chen, H.,Eberstadt, M.; Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.; Bioorg.Med.Chem.Lett., 17:4538-4544, 2007; PubMed: 17574412; DOI: 10.1016/j.bmcl.2007.05.096

実験手法

X-RAY DIFFRACTION (2.05 Å)