2PYW

Structure of A. thaliana 5-methylthioribose kinase in complex with ADP and MTR

2PYW の概要

• エントリーDOI: 10.2210/pdb2pyw/pdb
• 分子名称: Uncharacterized protein, CHLORIDE ION, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: 5-methylthioribose kinase, plant methionine recycling, refolding, transferase
• 由来する生物種: Arabidopsis thaliana (thale cress)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97978.95

構造登録者

Ku, S.Y. (登録日: 2007-05-16, 公開日: 2008-01-15, 最終更新日: 2023-08-30)

主引用文献

Ku, S.Y.,Cornell, K.A.,Howell, P.L.
Structure of A. thaliana 5-methylthioribose kinase in complex with ADP and MTR reveals a more occluded active site than its bacterial homolog
Bmc Struct.Biol., 7:70-70, 2007

PubMed Abstract: Metabolic variations exist between the methionine salvage pathway of humans and a number of plants and microbial pathogens. 5-Methylthioribose (MTR) kinase is a key enzyme required for methionine salvage in plants and many bacteria. The absence of a mammalian homolog suggests that MTR kinase is a good target for the design of specific herbicides or antibiotics.

PubMed: 17961230
DOI: 10.1186/1472-6807-7-70

実験手法

X-RAY DIFFRACTION (1.9 Å)