2PYM

HIV-1 PR mutant in complex with nelfinavir

2PYM の概要

• エントリーDOI: 10.2210/pdb2pym/pdb
• 関連するPDBエントリー: 2PYM 2PYN 2Q63 2Q64 2QAK
• 分子名称: PROTEASE RETROPEPSIN, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total)
• 機能のキーワード: resistance; nelfinavir, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22003.06

構造登録者

Rezacova, P.,Kozisek, M.,Saskova, K.,Brynda, J.,Konvalinka, J. (登録日: 2007-05-16, 公開日: 2008-02-26, 最終更新日: 2023-08-30)

• 主引用文献: Kozisek, M.,Bray, J.,Rezacova, P.,Saskova, K.,Brynda, J.,Pokorna, J.,Mammano, F.,Rulisek, L.,Konvalinka, J.; Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants; J.Mol.Biol., 374:1005-1016, 2007; PubMed: 17977555; DOI: 10.1016/j.jmb.2007.09.083

実験手法

X-RAY DIFFRACTION (1.9 Å)