2PVW

A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with 2-(phosphonomethyl)pentanedioic acid (2-PMPA)

2PVW の概要

• エントリーDOI: 10.2210/pdb2pvw/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase; 2-(phosphonomethyl)pentanedioic acid; 2-(pmpa), hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 82977.01

構造登録者

Barinka, C.,Lubkowski, J. (登録日: 2007-05-10, 公開日: 2007-05-22, 最終更新日: 2023-08-30)

• 主引用文献: Barinka, C.,Rovenska, M.,Mlcochova, P.,Hlouchova, K.,Plechanovova, A.,Majer, P.,Tsukamoto, T.,Slusher, B.S.,Konvalinka, J.,Lubkowski, J.; Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.; J.Med.Chem., 50:3267-3273, 2007; PubMed: 17567119; DOI: 10.1021/jm070133w

実験手法

X-RAY DIFFRACTION (1.71 Å)