2PR9
Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL
Summary for 2PR9
Entry DOI | 10.2210/pdb2pr9/pdb |
Related | 1BW8 |
Descriptor | AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide (3 entities in total) |
Functional Keywords | endocytosis, adaptor, internalization peptide complex, inhibitory neurotransmitter receptor |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Cell membrane (By similarity): P84092 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: P18508 |
Total number of polymer chains | 2 |
Total formula weight | 35336.07 |
Authors | Vahedi-Faridi, A.,Haucke, V.,Kittler, J.T.,Kukhtina, V.,Moss, S.J.,Saenger, W.,Chen, G.-J.,Tretter, V.,Smith, K.,Yan, Z.,McAinsh, K.,Arancibia-Carcamo, L. (deposition date: 2007-05-04, release date: 2008-03-18, Last modification date: 2023-08-30) |
Primary citation | Kittler, J.T.,Chen, G.,Kukhtina, V.,Vahedi-Faridi, A.,Gu, Z.,Tretter, V.,Smith, K.R.,McAinsh, K.,Arancibia-Carcamo, I.L.,Saenger, W.,Haucke, V.,Yan, Z.,Moss, S.J. Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc.Natl.Acad.Sci.Usa, 105:3616-3621, 2008 Cited by PubMed: 18305175DOI: 10.1073/pnas.0707920105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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