2PR9

Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL

2PR9 の概要

• エントリーDOI: 10.2210/pdb2pr9/pdb
• 関連するPDBエントリー: 1BW8
• 分子名称: AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide (3 entities in total)
• 機能のキーワード: endocytosis, adaptor, internalization peptide complex, inhibitory neurotransmitter receptor
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cell membrane (By similarity): P84092; Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: P18508
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35336.07

構造登録者

Vahedi-Faridi, A.,Haucke, V.,Kittler, J.T.,Kukhtina, V.,Moss, S.J.,Saenger, W.,Chen, G.-J.,Tretter, V.,Smith, K.,Yan, Z.,McAinsh, K.,Arancibia-Carcamo, L. (登録日: 2007-05-04, 公開日: 2008-03-18, 最終更新日: 2023-08-30)

• 主引用文献: Kittler, J.T.,Chen, G.,Kukhtina, V.,Vahedi-Faridi, A.,Gu, Z.,Tretter, V.,Smith, K.R.,McAinsh, K.,Arancibia-Carcamo, I.L.,Saenger, W.,Haucke, V.,Yan, Z.,Moss, S.J.; Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.; Proc.Natl.Acad.Sci.Usa, 105:3616-3621, 2008; PubMed: 18305175; DOI: 10.1073/pnas.0707920105

実験手法

X-RAY DIFFRACTION (2.51 Å)