2PR2
Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.
Summary for 2PR2
| Entry DOI | 10.2210/pdb2pr2/pdb |
| Descriptor | enoyl-ACP Reductase, (4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE (3 entities in total) |
| Functional Keywords | drug target of isoniazid, oxidoreductase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 1 |
| Total formula weight | 29405.30 |
| Authors | Vetting, M.W.,Argyrou, A.,Blanchard, J.S. (deposition date: 2007-05-03, release date: 2008-01-15, Last modification date: 2023-08-30) |
| Primary citation | Argyrou, A.,Vetting, M.W.,Blanchard, J.S. New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP J.Am.Chem.Soc., 129:9582-9583, 2007 Cited by PubMed: 17636923DOI: 10.1021/ja073160k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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