2PR2

Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.

2PR2 の概要

• エントリーDOI: 10.2210/pdb2pr2/pdb
• 分子名称: enoyl-ACP Reductase, (4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: drug target of isoniazid, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29405.30

構造登録者

Vetting, M.W.,Argyrou, A.,Blanchard, J.S. (登録日: 2007-05-03, 公開日: 2008-01-15, 最終更新日: 2023-08-30)

• 主引用文献: Argyrou, A.,Vetting, M.W.,Blanchard, J.S.; New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP; J.Am.Chem.Soc., 129:9582-9583, 2007; PubMed: 17636923; DOI: 10.1021/ja073160k

実験手法

X-RAY DIFFRACTION (2.5 Å)