2POW
The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
Summary for 2POW
Entry DOI | 10.2210/pdb2pow/pdb |
Related | 2POU 2POV |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-AMINO-6-(TRIFLUOROMETHYL)BENZENE-1,3-DISULFONAMIDE, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase ii, protein-inhibitor complexes, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29673.75 |
Authors | Alterio, V.,De Simone, G. (deposition date: 2007-04-27, release date: 2007-07-24, Last modification date: 2023-08-30) |
Primary citation | Alterio, V.,De Simone, G.,Monti, S.M.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies. Bioorg.Med.Chem.Lett., 17:4201-4207, 2007 Cited by PubMed: 17540563DOI: 10.1016/j.bmcl.2007.05.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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