2POG

Benzopyrans as Selective Estrogen Receptor b Agonists (SERBAs). Part 2: Structure Activity Relationship Studies on the Benzopyran Scaffold.

Summary for 2POG

• Entry DOI: 10.2210/pdb2pog/pdb
• Related: 2I0G
• Descriptor: Estrogen receptor, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL (3 entities in total)
• Functional Keywords: nuclear receptor, ligand-binding, lipid binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• Total number of polymer chains: 2
• Total formula weight: 57159.01

Authors

Richardson, T.I.,Norman, B.H.,Lugar, C.W.,Jones, S.A.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Dodge, J.A. (deposition date: 2007-04-26, release date: 2007-09-11, Last modification date: 2024-02-21)

• Primary citation: Richardson, T.I.,Norman, B.H.,Lugar, C.W.,Jones, S.A.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Dodge, J.A.; Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 2: structure-activity relationship studies on the benzopyran scaffold.; Bioorg.Med.Chem.Lett., 17:3570-3574, 2007; PubMed: 17485205; DOI: 10.1016/j.bmcl.2007.04.051

Experimental method

X-RAY DIFFRACTION (1.84 Å)