2PO5

Crystal structure of human ferrochelatase mutant with His 263 replaced by Cys

2PO5 の概要

• エントリーDOI: 10.2210/pdb2po5/pdb
• 関連するPDBエントリー: 1HRK 2PNJ 2PO7
• 分子名称: Ferrochelatase, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, CHOLIC ACID, ... (4 entities in total)
• 機能のキーワード: ferrochelatase; h263c; fe2s2 cluster; heme biosynthesis; protoheme; ferro-lyase; mature length; proteolytically processed mitochondrial inner membrane protein, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side: P22830
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85001.75

構造登録者

Dailey, H.A.,Wu, C.-K.,Horanyi, P.,Medlock, A.E.,Najahi-Missaoui, A.E.W.,Burden, A.,Dailey, T.A.,Rose, J.P. (登録日: 2007-04-25, 公開日: 2007-10-02, 最終更新日: 2024-02-21)

• 主引用文献: Dailey, H.A.,Wu, C.-K.,Horanyi, P.,Medlock, A.E.,Najahi-Missaoui, W.,Burden, A.E.,Dailey, T.A.,Rose, J.P.; Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis; Biochemistry, 46:7973-7979, 2007; PubMed: 17567154; DOI: 10.1021/bi700151f

実験手法

X-RAY DIFFRACTION (2.2 Å)