2PNU
Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744
Summary for 2PNU
Entry DOI | 10.2210/pdb2pnu/pdb |
Descriptor | Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ... (6 entities in total) |
Functional Keywords | har, dht, androgen receptor, ligand binding domain, lbd, androgen, hormone-gene regulation complex, hormone/gene regulation |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 1 |
Total formula weight | 31888.31 |
Authors | Cantin, L.,Faucher, F.,Couture, J.F.,Pereira de Jesus-Tran, K.,Legrand, P.,Ciobanu, C.L.,Singh, S.M.,Labrie, F.,Breton, R. (deposition date: 2007-04-25, release date: 2007-09-11, Last modification date: 2023-08-30) |
Primary citation | Cantin, L.,Faucher, F.,Couture, J.F.,de Jesus-Tran, K.P.,Legrand, P.,Ciobanu, L.C.,Frechette, Y.,Labrecque, R.,Singh, S.M.,Labrie, F.,Breton, R. Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12. J.Biol.Chem., 282:30910-30919, 2007 Cited by PubMed: 17711855DOI: 10.1074/jbc.M705524200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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