2PNU
Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744
2PNU の概要
エントリーDOI | 10.2210/pdb2pnu/pdb |
分子名称 | Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ... (6 entities in total) |
機能のキーワード | har, dht, androgen receptor, ligand binding domain, lbd, androgen, hormone-gene regulation complex, hormone/gene regulation |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus: P10275 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 31888.31 |
構造登録者 | Cantin, L.,Faucher, F.,Couture, J.F.,Pereira de Jesus-Tran, K.,Legrand, P.,Ciobanu, C.L.,Singh, S.M.,Labrie, F.,Breton, R. (登録日: 2007-04-25, 公開日: 2007-09-11, 最終更新日: 2023-08-30) |
主引用文献 | Cantin, L.,Faucher, F.,Couture, J.F.,de Jesus-Tran, K.P.,Legrand, P.,Ciobanu, L.C.,Frechette, Y.,Labrecque, R.,Singh, S.M.,Labrie, F.,Breton, R. Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12. J.Biol.Chem., 282:30910-30919, 2007 Cited by PubMed: 17711855DOI: 10.1074/jbc.M705524200 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
構造検証レポート
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