2PNT

Crystal structure of the PDZ domain of human GRASP (GRP1) in complex with the C-terminal peptide of the metabotropic glutamate receptor type 1

2PNT の概要

• エントリーDOI: 10.2210/pdb2pnt/pdb
• 分子名称: General receptor for phosphoinositides 1-associated scaffold protein, CHLORIDE ION (3 entities in total)
• 機能のキーワード: scaffold protein, structural genomics, structural genomics consortium, sgc, unknown function
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, perinuclear region : Q7Z6J2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22140.39

構造登録者

Elkins, J.,Papagrigoriou, E.,Cooper, C.,Gileadi, C.,Uppenberg, J.,Bray, J.,von Delft, F.,Pike, A.C.W.,Ugochukwu, E.,Umeano, C.,Gileadi, O.,Edwards, A.,Arrowsmith, C.H.,Weigelt, J.,Sundstrom, M.,Doyle, D.A.,Structural Genomics Consortium (SGC) (登録日: 2007-04-25, 公開日: 2007-05-08, 最終更新日: 2023-08-30)

• 主引用文献: Elkins, J.M.,Gileadi, C.,Shrestha, L.,Phillips, C.,Wang, J.,Muniz, J.R.,Doyle, D.A.; Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms; Protein Sci., 19:731-741, 2010; PubMed: 20120020; DOI: 10.1002/pro.349

実験手法

X-RAY DIFFRACTION (2.148 Å)