2PJO

Ricin a-chain (recombinant) complex with n-methylurea

「1ZB0」から置き換えられました

2PJO の概要

• エントリーDOI: 10.2210/pdb2pjo/pdb
• 関連するPDBエントリー: 2P8N 2R2X 2R3D
• 分子名称: Ricin (EC 3.2.2.22), SULFATE ION, N-METHYLUREA, ... (4 entities in total)
• 機能のキーワード: ricin, ricinus communis, n-glycosidase, toxin, hydrolase
• 由来する生物種: Ricinus communis (castor bean)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30334.16

構造登録者

Carra, J.H.,Mchugh, C.A.,Mulligan, S.,Machiesky, L.M.,Millard, C.B. (登録日: 2007-04-16, 公開日: 2007-11-20, 最終更新日: 2023-08-30)

主引用文献

Carra, J.H.,McHugh, C.A.,Mulligan, S.,Machiesky, L.M.,Soares, A.S.,Millard, C.B.
Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.
Bmc Struct.Biol., 7:72-72, 2007

PubMed Abstract: Ricin is a potent toxin and known bioterrorism threat with no available antidote. The ricin A-chain (RTA) acts enzymatically to cleave a specific adenine base from ribosomal RNA, thereby blocking translation. To understand better the relationship between ligand binding and RTA active site conformational change, we used a fragment-based approach to find a minimal set of bonding interactions able to induce rearrangements in critical side-chain positions.

PubMed: 17986339
DOI: 10.1186/1472-6807-7-72

実験手法

X-RAY DIFFRACTION (1.8 Å)