2PDZ

SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES

2PDZ の概要

• エントリーDOI: 10.2210/pdb2pdz/pdb
• 分子名称: SYNTROPHIN, PEPTIDE GVKESLV (2 entities in total)
• 機能のキーワード: syntrophin pdz domain, voltage-gated sodium channel, complex (syntrophin-peptide), complex (syntrophin-peptide) complex, complex (syntrophin/peptide)
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side: Q61234
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 9831.44

構造登録者

Schultz, J.,Hoffmueller, U.,Ashurst, J.,Krause, G.,Schmieder, P.,Macias, M.,Schneider-Mergener, J.,Oschkinat, H. (登録日: 1997-12-10, 公開日: 1998-12-30, 最終更新日: 2024-05-22)

主引用文献

Schultz, J.,Hoffmuller, U.,Krause, G.,Ashurst, J.,Macias, M.J.,Schmieder, P.,Schneider-Mergener, J.,Oschkinat, H.
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels.
Nat.Struct.Biol., 5:19-24, 1998

PubMed Abstract: Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain.

PubMed: 9437424
DOI: 10.1038/nsb0198-19

実験手法

SOLUTION NMR