2PCC

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN ELECTRON TRANSFER PARTNERS, CYTOCHROME C PEROXIDASE AND CYTOCHROME C

2PCC の概要

• エントリーDOI: 10.2210/pdb2pcc/pdb
• 分子名称: CYTOCHROME C PEROXIDASE, ISO-1-CYTOCHROME C, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase/electron transport, oxidoreductase-electron transport complex
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Mitochondrion matrix: P00431; Mitochondrion intermembrane space: P00044
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94344.95

構造登録者

Pelletier, H.,Kraut, J. (登録日: 1993-04-14, 公開日: 1993-07-15, 最終更新日: 2024-02-21)

主引用文献

Pelletier, H.,Kraut, J.
Crystal structure of a complex between electron transfer partners, cytochrome c peroxidase and cytochrome c.
Science, 258:1748-1755, 1992

PubMed Abstract: The crystal structure of a 1:1 complex between yeast cytochrome c peroxidase and yeast iso-1-cytochrome c was determined at 2.3 A resolution. This structure reveals a possible electron transfer pathway unlike any previously proposed for this extensively studied redox pair. The shortest straight line between the two hemes closely follows the peroxidase backbone chain of residues Ala194, Ala193, Gly192, and finally Trp191, the indole ring of which is perpendicular to, and in van der Waals contact with, the peroxidase heme. The crystal structure at 2.8 A of a complex between yeast cytochrome c peroxidase and horse heart cytochrome c was also determined. Although crystals of the two complexes (one with cytochrome c from yeast and the other with cytochrome c from horse) grew under very different conditions and belong to different space groups, the two complex structures are closely similar, suggesting that cytochrome c interacts with its redox partners in a highly specific manner.

PubMed: 1334573

実験手法

X-RAY DIFFRACTION (2.3 Å)