2PBJ

GSH-heme bound microsomal prostaglandin E synthase

2PBJ の概要

• エントリーDOI: 10.2210/pdb2pbj/pdb
• 分子名称: Prostaglandin E synthase 2, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: prostaglandin e synthase, gsh-heme bound enzyme, dual function enzyme, isomerase, lyase
• 由来する生物種: Macaca fascicularis (crab-eating macaque)
• 細胞内の位置: Golgi apparatus membrane; Single-pass membrane protein (By similarity). Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region (By similarity): Q9N0A4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 136436.29

構造登録者

Takusagawa, F.,Yamada, T. (登録日: 2007-03-28, 公開日: 2008-02-12, 最終更新日: 2024-02-21)

• 主引用文献: Yamada, T.,Takusagawa, F.; PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.; Biochemistry, 46:8414-8424, 2007; PubMed: 17585783; DOI: 10.1021/bi700605m

実験手法

X-RAY DIFFRACTION (2.8 Å)