2P8N

Ricin a-chain (recombinant) complex with adenine

2P8N の概要

• エントリーDOI: 10.2210/pdb2p8n/pdb
• 関連するPDBエントリー: 1ZAM 1ZB0 1ZB2
• 分子名称: Ricin A chain, SULFATE ION, ADENINE, ... (4 entities in total)
• 機能のキーワード: ricin; ricinus communis; n-glycosidase; toxin, hydrolase
• 由来する生物種: Ricinus communis (castor bean)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30491.27

構造登録者

Carra, J.H.,Mchugh, C.A.,Mulligan, S.,Machiesky, L.M.,Millard, C.B. (登録日: 2007-03-22, 公開日: 2007-11-20, 最終更新日: 2023-08-30)

主引用文献

Carra, J.H.,McHugh, C.A.,Mulligan, S.,Machiesky, L.M.,Soares, A.S.,Millard, C.B.
Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site
BMC Struct.Biol., 7:72-72, 2007

PubMed Abstract: Ricin is a potent toxin and known bioterrorism threat with no available antidote. The ricin A-chain (RTA) acts enzymatically to cleave a specific adenine base from ribosomal RNA, thereby blocking translation. To understand better the relationship between ligand binding and RTA active site conformational change, we used a fragment-based approach to find a minimal set of bonding interactions able to induce rearrangements in critical side-chain positions.

PubMed: 17986339
DOI: 10.1186/1472-6807-7-72

実験手法

X-RAY DIFFRACTION (1.94 Å)