2P71

Bombyx mori pheromone binding protein bound to iodohexadecane

2P71 の概要

• エントリーDOI: 10.2210/pdb2p71/pdb
• 関連するPDBエントリー: 1DQE 2FJY 2P70
• 分子名称: pheromone-binding protein, 1-IODOHEXADECANE (3 entities in total)
• 機能のキーワード: alpha-helical, binding pocket, liganded, attractant
• 由来する生物種: Bombyx mori (domestic silkworm)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15274.33

構造登録者

Lautenschlager, C.L.,Clardy, J. (登録日: 2007-03-19, 公開日: 2007-04-10, 最終更新日: 2024-11-20)

主引用文献

Lautenschlager, C.,Leal, W.S.,Clardy, J.
Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.
Structure, 15:1148-1154, 2007

PubMed Abstract: Insect pheromone-binding proteins (PBPs) transport sex pheromones through the aqueous layer surrounding G protein-coupled receptors that initiate signaling events leading to mating. This PBP-receptor system strongly discriminates between ligands with subtle structural differences, but it has proved difficult to distinguish the degree of discrimination of the PBP from that of the G protein-coupled receptor. The three-dimensional structures of the PBP of Bombyx mori, the silkworm moth, both with and without its cognate ligand bombykol ([E,Z]-10,12-hexadecadienol), have been determined by X-ray crystallography and NMR. In this paper, the structures of the same binding protein with bound iodohexadecane and bell pepper odorant were determined at 1.9 and 2.0 A, respectively. These structures illustrate the remarkable plasticity in the ligand binding site of the PBP, but suggest the protein might still act as a filter during pheromone signal processing.

PubMed: 17850754
DOI: 10.1016/j.str.2007.07.013

実験手法

X-RAY DIFFRACTION (2.006 Å)