2P3D

Crystal Structure of the multi-drug resistant mutant subtype F HIV protease complexed with TL-3 inhibitor

2P3D の概要

• エントリーDOI: 10.2210/pdb2p3d/pdb
• 関連するPDBエントリー: 2P3A 2P3B 2P3C
• 関連するBIRD辞書のPRD_ID: PRD_000434
• 分子名称: Pol protein, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
• 機能のキーワード: multi-drug resistant mutant subtype f hiv protease, tl-3 inhibitor, non-b hiv protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22634.60

構造登録者

Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. (登録日: 2007-03-08, 公開日: 2007-04-24, 最終更新日: 2024-04-03)

• 主引用文献: Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I.; Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development.; J.Mol.Biol., 369:1029-1040, 2007; PubMed: 17467738; DOI: 10.1016/j.jmb.2007.03.049

実験手法

X-RAY DIFFRACTION (2.8 Å)