2P3B

Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor

2P3B の概要

• エントリーDOI: 10.2210/pdb2p3b/pdb
• 関連するPDBエントリー: 2P3A 3TLH
• 関連するBIRD辞書のPRD_ID: PRD_000434
• 分子名称: protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, ... (4 entities in total)
• 機能のキーワード: wild type subtype b hiv protease, tl-3 inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22594.81

構造登録者

Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. (登録日: 2007-03-08, 公開日: 2007-04-24, 最終更新日: 2024-04-03)

• 主引用文献: Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I.; Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development.; J.Mol.Biol., 369:1029-1040, 2007; PubMed: 17467738; DOI: 10.1016/j.jmb.2007.03.049

実験手法

X-RAY DIFFRACTION (2.1 Å)