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2OYV

Neurotensin in DPC micelles

2OYV の概要
エントリーDOI10.2210/pdb2oyv/pdb
関連するPDBエントリー2OYW
NMR情報BMRB: 15145
分子名称neurotensin (1 entity in total)
機能のキーワードtype i turn, neuropeptide
タンパク質・核酸の鎖数1
化学式量合計1675.95
構造登録者
Monti, J.P.,Coutant, J.,Curmi, P.A. (登録日: 2007-02-23, 公開日: 2007-05-08, 最終更新日: 2024-10-30)
主引用文献Coutant, J.,Curmi, P.A.,Toma, F.,Monti, J.P.
NMR Solution Structure of Neurotensin in Membrane-Mimetic Environments: Molecular Basis for Neurotensin Receptor Recognition.
Biochemistry, 46:5656-5663, 2007
Cited by
PubMed Abstract: Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
PubMed: 17441729
DOI: 10.1021/bi602567p
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 2oyv
検証レポート(詳細版)ダウンロードをダウンロード

227561

件を2024-11-20に公開中

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