2OXH

The SOXYZ Complex of Paracoccus Pantotrophus

2OXH の概要

• エントリーDOI: 10.2210/pdb2oxh/pdb
• 関連するPDBエントリー: 2OX5 2OXG
• 分子名称: SoxZ protein, SoxY protein, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: immunoglobulin-like beta-sandwich fold, transport protein
• 由来する生物種: Paracoccus denitrificans; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 96904.64

構造登録者

Sauve, V.,Berks, B.C.,Hemmings, A.M. (登録日: 2007-02-20, 公開日: 2007-05-22, 最終更新日: 2023-08-30)

主引用文献

Sauve, V.,Bruno, S.,Berks, B.C.,Hemmings, A.M.
The SoxYZ Complex Carries Sulfur Cycle Intermediates on a Peptide Swinging Arm.
J.Biol.Chem., 282:23194-23204, 2007

PubMed Abstract: The bacterial Sox (sulfur oxidizing) system allows the utilization of inorganic sulfur compounds in energy metabolism. Central to this process is the SoxYZ complex that carries the pathway intermediates on a cysteine residue near the C terminus of SoxY. Crystal structures have been determined for Paracoccus pantotrophus SoxYZ with the carrier cysteine in the underivatized state, conjugated to the polysulfide mimic beta-mercaptoethanol, and as the sulfonate adduct pathway intermediate. The carrier cysteine is located on a peptide swinging arm and is bracketed on either side by diglycine dipeptides acting as molecular universal joints. This structure provides a novel solution to the requirement that the cysteine-bound intermediates be able to access and orient themselves within the active sites of multiple partner enzymes. Adjacent to the swinging arm there is a conserved, deep, apolar pocket into which the beta-mercaptoethanol adduct extends. This pocket would be well suited to a role in protecting labile pathway intermediates from adventitious reactions.

PubMed: 17522046
DOI: 10.1074/jbc.M701602200

実験手法

X-RAY DIFFRACTION (2.35 Å)