2OW9
Crystal structure analysis of the MMP13 catalytic domain in complex with specific inhibitor
Summary for 2OW9
Entry DOI | 10.2210/pdb2ow9/pdb |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | complex crystal structure, martix metalloproteinase, mmp13, specific mmp13 inhibitor, s1' mmp13 inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 39711.86 |
Authors | Pavlovsky, A.G. (deposition date: 2007-02-15, release date: 2007-02-27, Last modification date: 2023-08-30) |
Primary citation | Johnson, A.R.,Pavlovsky, A.G.,Ortwine, D.F.,Prior, F.,Man, C.F.,Bornemeier, D.A.,Banotai, C.A.,Mueller, W.T.,McConnell, P.,Yan, C.,Baragi, V.,Lesch, C.,Roark, W.H.,Wilson, M.,Datta, K.,Guzman, R.,Han, H.K.,Dyer, R.D. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J.Biol.Chem., 282:27781-27791, 2007 Cited by PubMed: 17623656DOI: 10.1074/jbc.M703286200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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